I know you're all happy about being forty and all, and I really am glad that you're so well adjusted, I really am. But here's the thing, and I'll try to put this as gently as possible, you are not as young as you used to be. Therefore it is time that you start making better choices. I'm sorry but you cannot stay up all night helping your sister with her baby AND forget to take your thyroid medicine for a week. You cannot do it. One or the other maybe, but NOT BOTH. That is why you feel like death right now, just in case you were wondering.
And you especially can't do these things when you are planning to run off and act like a teenager with your BFF and sister this weekend. Do you want to drive off a ridge while you're headed down to the valley? Hmm? Because I'm thinking you'll make your family really mad at you if you do. So go take your medicine (you did finally pick it up I assume) and go take a nap and lets try harder to be more responsible shall we. Okay good.
Love always (even when you don't deserve it),